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BBDC Newsletter

BBDC NEWS   Vol. 10, No. 4 -- June 2010

FUNDING OPPORTUNITIES

TRAINEE TRAVEL AWARDS 2010/2011 (PERIOD 1)
FOR TRAVEL OCCURRING BETWEEN JULY 1 AND DECEMBER 31, 2010

Awards of up to $1,000 (Canadian) are available to trainees who will be traveling to a national or international meeting between July 1 and December 31, 2010 to present a first-author abstract.  The content of the abstract must be directly related to an area of diabetes research.  At the time of abstract submission to the meeting, the applicant must be either: A) a registered University of Toronto graduate student; B) a post-doctoral research fellow having received a PhD within the last 5 years; or C) a clinical fellow or medical resident having received an MD within the last 9 years. The applicant’s supervisor must hold a full-time faculty appointment with the University of Toronto and must also be a registered member* of the BBDC at the time of application submission.  The deadline for receipt of applications is 5 p.m., Tuesday, October 5, 2010.  For complete award details and application instructions please see the following web page: http://www.bbdc.org/fundingOpp/travel.htm .

Upcoming Funding Opportunities:
Information on the following programs will be posted on the BBDC’s web site soon:

  • Pilot Grants for Innovative Activities Related to Diabetes Education, Management & Care.  Deadline to submit letters of intent: September 28, 2010.
  • Diabetes Educator of the Year Award 2010.  Nomination deadline: November 23, 2010

* Those who are new to the field of diabetes research, education or care and are not members of the BBDC can request free membership by contacting the Centre prior to submitting an application. For more information about BBDC Membership, please view the MEMBERSHIP section of our web site at http://www.bbdc.org/membership/index.htm .


AWARD RESULTS**

ANNUAL TRAINEE AWARDS 2009/2010

Prize Applicant Supervisor Abstract Title

 1st Prize

Safina Ali

Dr. Daniel Drucker

Genetic ablation of glucagon and GLP-1 receptors in Gcgr-/-;GLP-1r-/- mice reveals novel compensatory mechanisms upregulated to maintain insulin secretion

2nd Prize

Liang Xi

Dr. Gary Lewis

C-reactive Protein Induces Hepatic Insulin Resistance and Insulin Signaling Defects in Rats: Role of MAP kinases

3rd Prize

Linyuan Wang

Dr. Minna Woo

PTEN Deletion in Pancreatic Beta Cells Protects Against Type 2 Diabetes Without Promoting Tumorigenesis

Honourable Mention

Diana Choi

Dr. Minna Woo

Erythropoietin provides diabetes protection through direct effects on the pancreatic beta cells

Honourable Mention

Gavasker Sivaskandarajah

Dr. Susan Quaggin

Local vascular endothelial growth factor-A protects the diabetic kidney

Honourable Mention

Victor S.C. Wong

Dr. Patricia Brubaker

The role of R-spondin1 in pancreatic beta-cells in vivo

 

ARCHIE SOPMAN DIABETES RESEARCH AND EDUCATION AWARDS 2010

Recipient Purpose Amount

Lynn Baughan

Travel to diabetes meeting

Up to $1,000 CAD

Lucia Chan

Travel to diabetes meeting

Up to $1,000 CAD

Kathy Cohen

Travel to diabetes meeting

Up to $1,000 CAD

Margaret De Melo

Travel to diabetes meeting

Up to $1,000 CAD

Doreen Klar

Travel to diabetes meeting

Up to $1,000 CAD

Louisa Li

Travel to diabetes meeting

Up to $1,000 CAD

Kitty Mak

Travel to diabetes meeting

Up to $1,000 CAD

Ann Murphy

Travel to diabetes meeting

Up to $1,000 CAD

Ana Offenheim

Travel to diabetes meeting

Up to $1,000 CAD

Artee Srivastava

Travel to diabetes meeting

Up to $1,000 CAD

Mary Weiland

Travel to diabetes meeting

Up to $280 CAD

 

POST-DOCTORAL FELLOWSHIPS 2010/2011

Applicant Supervisor Title of Research Award

Robert Bandsma
(DECLINED)

Dr. Gary Lewis

The role of glucagon-like peptides on intestinal lipid metabolism

BBDC Postdoctoral Fellowship

Christina Basford

Dr. Michael Wheeler

The functional and molecular characterization of insulin-producing cells derived from embryonic stem cells

BBDC Postdoctoral Fellowship

Shlomit Boguslavsky

Dr. Amira Klip

alpha-Actinin-4: from bundling actin filaments to acting as a “sensor” of insulin

BBDC Fellowship in Diabetes Care

Danna Breen

Dr. Tony Lam

Nutrient Sensing in the Brain

BBDC Postdoctoral Fellowship

Jonathan Campbell

Dr. Daniel Drucker

Defining the tissue specific role(s) of Glucose-Dependent Insulinotropic Polypeptide on whole body glucose metabolism

BBDC Postdoctoral Fellowship

Karen Eny

Dr. Andrew Paterson

Diet, genetics, HbA1c and long-term complications in subjects with type 1 diabetes (T1DM): A genome-wide association study (GWAS) approach

BBDC Fellowship in Diabetes Care

Claudia Gordijo

Dr. Xiao Yu (Shirley) Wu

Development of a Chemically Controlled Closed-Loop Insulin Delivery Device Prototype for Treatment of Type 1 Diabetes

BBDC Postdoctoral Fellowship

Sara Hamilton

Dr. Pamela Ohashi

Role of the Hyaluronan Receptor, Rhamm in T cell Function and Autoimmune Responses

Hugh Sellers Postdoctoral  Fellowship

Girish Kewalramani
(DECLINED)

Dr. Amira Klip

Interplay between monocytes/macrophages and cardiomyocytes in diet-induced diabetes

BBDC Fellowship in Diabetes Care

Min-Suk Kim
(DECLINED)

Dr. Daniel Drucker

The role of incretins and dipeptidyl peptidase-4 in the pathophysiology of athersclerosis

BBDC Postdoctoral Fellowship

Ganesh Sangle

Dr. Patricia Brubaker

Role of clock genes in the regulation of glucagon-like peptide-1 secretion

BBDC Fellowship in Diabetes Care

Jessica Yue

Dr. Tony Lam

Glucagon action in the control of glucose homeostasis

BBDC Postdoctoral Fellowship

Dan Zhu

Dr. Herbert Gaisano

Rescuing insulin exocytotic deficiency in Type 2 diabetes

BBDC Postdoctoral Fellowship

 

PILOT GRANTS FOR INNOVATIVE ACTIVITIES RELATED TO DIABETES EDUCATION, MANAGEMENT, AND CARE 2010/2011

Applicants Title of Research Amount

Margaret De Melo
Enza Gucciardi
Lina Amaral
Dr. Denice Feig

Exploring Sex Differences in Diabetes Preventative Care in Canada

$10,000

 

TRAINEE TRAVEL AWARDS - PERIOD 2
FOR TRAVEL OCCURRING BETWEEN JANUARY 1 AND JUNE 30, 2010

Applicant Supervisor(s) Abstract Title

Leena Amin

Dr. Baiju Shah

Impact of gender and socioeconomic status on extremity amputation in individuals with diabetes

Danna Breen

Dr. Adria Giacca

Local Insulin Application on the Carotid Artery Inhibits Neointimal Formation

June H. J. Guo

Dr. Adria Giacca

Role of SIRT1 in the Effect of Resveratrol to Decrease Neointimal Growth after Arterial Injury

Alexandre Hardy

Dr. Michael Wheeler

The Role of ZnT8 in Insulin Resistance and Type 2 Diabetes

Sheena Kayaniyil

Dr. Anthony Hanley

Association of Parathyroid Hormone (PTH) with Insulin Resistance (IR) and Beta-cell Dysfunction in Non-Diabetic Subjects

Girish Kewalramani

Dr. Amira Klip

Palmitate-activated macrophages confer insulin resistance to muscle cells by a mechanism involving PKC theta

Andrea Kokorovic

Dr. Tony Lam

Duodenal Protein Kinase C Regulates Glucose Production

Ellen Koo

Dr. Herbert Gaisano

Syntaxin-3 Regulates Exocytosis of Newcomer Insulin Granules During Biphasic Glucose-Stimulated Insulin Secretion in Pancreatic Beta Cells

Benjamin Lamont

Dr. Daniel Drucker

Pancreatic GLP-1 receptor activation is sufficient for GLP-1R-dependent control of glucose metabolism in vivo

Weijuan Shao

Dr. Tianru Jin

Cyclic AMP signaling stimulates proteasome degredation of Thioredoxin interacting protein (TxNIP) in pancreatic beta-cells

Madura Siva

Dr. Allen Volchuk

Herp is required for ERAD-mediated degradation of misfolded insulin and maintaining pancreatic beta-cell survival

Linyuan Wang

Dr. Minna Woo

PTEN Deletion in Pancreatic Beta Cells Protects Against Type 2 Diabetes without Promoting Tumorigenesis

Victor Wong

Dr. Patricia Brubaker

The role of R-spondin 1 in pancreatic beta-cells in vivo

Clair S. Yang

Dr. Tony Lam

Hypothalamic AMPK regulates glucose production

Jessica Yue

Dr. Mladen Vranic and
Dr. Adria Giacca

Amelioration of Hypoglycemia via Somatostatin Receptor Type 2 Antagonism in Recurrently Hypoglycemic Diabetic Rats

**An essential condition of all BBDC programs is the acknowledgement of BBDC support, where appropriate, in all publications relevant to the BBDC-supported research program. Failure to appropriately acknowledge the BBDC’s support in relevant publications will be considered grounds for suspending future eligibility for BBDC funding programs.


BBDC CORE LABORATORY

The BBDC Core Laboratory provides analytical and technical support to the University of Toronto diabetes research community.  A wide range of research quality assays are provided for investigator initiated clinical or basic research as well as for industry sponsored trials. Please see the Core Laboratory section of the BBDC’s web site at http://www.bbdc.org/laboratories/index.htm for a complete description of assays and services currently available.


ACKNOWLEDGEMENTS

We would like to express our sincerest gratitude and appreciation to the following:

  • The members of our Research Committee and our Diabetes Care and Education Committee who volunteer their time to review applications for the Centre’s funding programs and to organize educational events on behalf of the BBDC.
  • The members of our Executive Committee.
  • Everyone who participated in our Recent Advances in Beta Cell Biology-Scientific and Clinical Implications Satellite Symposium which was held in October 2009.
  • Everyone who participated in our 21st Annual Scientific Day which was held in May 2010.
  • Everyone who participated in our Bariatric Surgery Workshop–Which Patients to Refer and Why which was held on June 11.
  • Dr. Tony Lam, our 2010 Charles Hollenberg Summer Studentship Program Coordinator.
  • Supporters who helped make our educational events possible over the past year: University Health Network, Bristol-Myers Squibb/AstraZeneca, Eli Lilly, Merck, Novo Nordisk, Pfizer, and Sanofi-Aventis.

BBDC membership is free and open to individuals involved in full or part-time diabetes research, education, and patient care (eg. scientists, physicians, nurses, dietitians, pharmacists, etc.), and whose primary appointment/employment (more than 50% of total salary) is with the University of Toronto or one of its affiliated institutions.  Staff at both fully and partially affiliated institutions are eligible to apply for membership. For more information about BBDC Membership, please view the MEMBERSHIP section of our web site at http://www.bbdc.org/membership/index.htm.

BBDC News is published in September, December, March and June of each year.
Current and past issues are available on our website.

DIRECTOR: DANIEL J. DRUCKER, MD, FRCPC
Banting & Best Diabetes Centre
Faculty of Medicine, University of Toronto
Located at the Toronto General Hospital
200 Elizabeth Street
Eaton Building, 12th Floor, Room 12E248
Toronto, Ontario M5G 2C4
Phone: (416) 978-4656 • Fax: (416) 978-4108
E-mail:
diabetes.bbdc@utoronto.ca • Website: www.bbdc.org