Research at the University
Profiles of BBDC Members involved in diabetes related research (M - Z):
| On this page: M N O P Q R S T U V W X Y Z |
View A to L |
M
Mahmud, Farid H.,
MD, FRCPC
Assistant Professor, Faculty of Medicine, University of Toronto
Division of Pediatric Endocrinology, The Hospital for Sick Children
| Address: | The Hospital for Sick Children 555 University Avenue Toronto, Ontario M5G 1X8 |
|---|---|
| Phone/FAX: E-mail: |
416-813-6218 FAX: 416-813-6304 farid.mahmud@sickkids.ca |
| Research Interests: | As a pediatric endocrinologist who cares for children with diabetes, obesity and other chronic medical conditions on a daily basis, I am concerned about the prospects for their future health. This has driven me to seek answers to some of the meaningful questions that are going to benefit their health and this has prompted me to pursue a clinical research program. My research interests include the study of conditions associated with type 1 diabetes, such as celiac disease and the evaluation of early atherosclerotic risk factors in young patients with endocrine conditions who are at high risk of cardiovascular disease including both type 1 and type 2 diabetes, insulin resistance and obesity. I have conducted clinical studies to identify patients at risk and study the impact of this process on the health of these children. These studies are also evaluating interrelated risk factors for atherosclerosis in these high risk populations and the effectiveness of lifestyle, diet and drug therapy treatment strategies. Specifically we evaluated dietary intake in patients with type 1 diabetes as well as standardized activity assessments which showed high rates of dietary fat intake and inactivity, which worsened during adolescence. As part of my research, I adapted an innovative method to study endothelial function as a marker of early atherosclerosis which we able to evaluate as a reversible indicator of disease with the potential to assess the effectiveness of different treatment strategies on reducing early atherosclerotic changes. Longer term, the findings of this research will be used to develop guidelines for clinical practice, prevention and treatment strategies. It is hoped that the effective translation of this research into clinical practice will help to manage cardiovascular disease risk in children with the ultimate goal of cardiovascular disease prevention. |
| Publications: |
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Mamdani, Muhammad,
PharmD, MA, MPH
Associate Professor, Department of Health Policy, Management, and
Evaluation of the Faculty of
Medicine and the Leslie Dan Faculty of Pharmacy, University of Toronto
Director, Applied Health Research Centre, Li Ka Shing Knowledge
Institute,St. Michael’s Hospital
| Address: | St. Michael’s
Hospital 30 Bond Street Toronto, Ontario, M5B 1W8 |
|---|---|
| Phone/FAX: E-mail: Web site: | Phone: 416-864-3037
Fax: 416-864-301 E-mail: mamdanim@smh.ca Website: www.ahrconline.com |
| Research Interests: | The Applied Health Research Centre (AHRC) is a comprehensive, not-for-profit, academic clinical research centre that houses leading clinical research methodologists and statisticians as well as operations experts including contracts and finance experts, study management coordinators, and research informatics specialists. Further, the AHRC also houses industry-standard and highly secure data management infrastructure. The AHRC has extensive experience designing and implementing phase 2b-4 clinical trials as well as nonrandomized studies such as patient registries and retrospective database studies. The infrastructure and support services are available to all academic clinical researchers and is well suited for diabetes-related clinical research. |
| Publications: |
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McCulloch, Christopher
Professor, Faculty of Dentistry; Cross-appointed to Department of Laboratory
Medicine and Pathobiology, Faculty of Medicine
Canada
| Address: | Matrix Dynamics Group Room 244, 150 College Street Toronto, Ontario M5S 3E2 |
|---|---|
| Phone/FAX: E-mail: Web site: | 416-978-1258 FAX:
416-978-5956 Christopher.Mcculloch@utoronto.ca www.matrixdynamics.ca |
| Research Interests: | My laboratory is focused on the
signals arising from the extracellular matrix that regulate the
metabolic activities of fibroblasts. In the context of diabetes,
I am interested in the notion that diabetes-induced glycation of
collagen may impact the function and differentiation of
fibroblasts in the cardiac interstitium. Accordingly, I cardiac
fibroblasts may convert to myofibroblasts, cells that contribute
to the fibrosis that is observed in diabetic cardiomyopathy. |
| Publications: | Yuen A, Laschinger C, Talior I, Lee W, Chan M, Birek J, Young EW, Sivagurunathan K, Won E, Simmons CA, McCulloch CA. Methylglyoxal-modified collagen promotes myofibroblast differentiation. Matrix Biol. 2010 Jul;29(6):537-48 |
McIntyre, Roger S.
Associate Professor of Psychiatry and Pharmacology, University of
Toronto
Head, Mood Disorders Psychopharmacology Unit (MDPU), University Health
Network
| Address: | Toronto Western Hospital 399 Bathurst Street, MP9-325 Toronto, Ontario M5T 2S8 |
|---|---|
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Phone/FAX: E-mail: | 416-603-5279 FAX: 416-603-5368
roger.mcintyre@uhn.on.ca |
| Research Interests: | Individuals with mood disorders are differentially affected by abnormalities in glucose handling, hyperglycemia, and diabetes mellitus. Evidence indicates that both mood disorders and diabetes are highly associated with neurocognitive impairment as well as changes in brain volume and structure. Points of pathophysiological commonality have been implicated between mood disorders and diabetes and include alterations in metabolic effector systems, immunoinflammatory dysregulation, oxidative stress, and incretin systems. We have coined the moniker “Metabolic Syndrome Type II” to characterize these points of commonality. The Mood Disorder Psychopharmacology Unit (MDPU) is engaged in a plethora of both descriptive and interventional studies that aim to identify the effect of abnormal glucose homeostasis, insulin resistance, and incretin dysregulation on brain structure and function. The MDPU welcomes multidiscipline centre of excellence and research characterizing the psychiatry and endocrinology interface. |
| Publications: |
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Moriarty, Tara,
PhD, BA, BSc
Assistant Professor, Matrix Dynamics Group, Faculty of Dentistry
Assistant Professor, Department of Laboratory Medicine and Pathobiology,
Faculty of Medicine
| Address: | Matrix Dynamics Group Toronto, Ontario M5S 3E2 |
|---|---|
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Phone/FAX: E-mail: Web site: | Phone 416-978-6367 FAX: 416-978-5956 www.matrixdynamics.ca |
| Research Interests: | We are a newly established research group studying systemic dissemination mechanisms of bloodborne bacterial pathogens, with a focus on the Lyme disease pathogen, Borrelia burgdorferi. Lyme disease is the most common vector-borne infection in the industrialized world, and its incidence is increasing rapidly, in parallel with rising rates of obesity and diabetes. Systemic dissemination of pathogens causes most of the mortality due to bacterial infection, but remains poorly understood. One critical step in dissemination is microbe adhesion to blood vessel surfaces in the face of fluid shear force. Vascular adhesion enables pathogens to decelerate and transmigrate through vessels to reach extravascular tissues in joints, heart and brain where secondary infection is established. B. burgdorferi adheres more readily to sites of turbulent, altered blood flow (Moriarty et al., 2008). This observation, together with the epidemiological profile of Lyme disease, prompted us to examine the effect of blood flow-altering conditions such as diet-induced obesity on B. burgdorferi dissemination in mice. In a recent pilot study, we found that diet-induced obesity significantly enhances host susceptibility to disseminated Borrelia infection, with a 2.5-9-fold increase in bacterial burden in most tissues. We are now investigating the role of diabetes in host susceptibility to Lyme disease. |
| Publications: |
As of January 2012, we have not yet published our preliminary data describing
the role of diet-induced obesity in promoting host susceptibility to
disseminated infection with the Lyme disease pathogen. The paper below describes
our most recently published work on B.
burgdorferi dissemination.
|
N
Nathan, Paul C.,
MD, MSc
Associate Professor, Department of Paediatrics, Division of Haematology/Oncology, University of Toronto
Associate Scientist, Hospital for Sick Children Research Institute
| Address: | The Hospital for Sick Children 555 University Avenue Toronto, Ontario M5G 1X8 |
|---|---|
| Phone/FAX: E-mail: Web site: |
416-813-8795 FAX: 416-813-5327 paul.nathan@sickkids.ca http://www.sickkids.ca/AboutSickKids/Directory/People/N/Paul-Nathan.html |
| Research Interests: | Dr. Nathan’s research focuses on long-term outcomes in survivors of childhood cancer. His interests include obesity and other metabolic sequelae of cancer treatment, as well as cardiac outcomes in children treated with cardiotoxic chemotherapy or radiation. In addition, he is interested in health care utilization and screening/surveillance late effects in adult survivors of childhood cancer. |
| Publications: |
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Ng, Dominic S.,
PhD, MD, FRCPC
AssociateProfessor, Department of Medicine, Division of Endocrinology &
Metabolism; Department of Physiology and Department of Laboratory
Medicine and Pathobiology, University of Toronto
Scientist, Keenan Research Center, Li Ka Shing Knowledge Institute, St
Michael’s Hospital.
| Address: | St. Michael's Hospital 30 Bond Street Shuter Wing, 3rd Floor, Room 3-041 Toronto, Ontario M5B 1W8 |
|---|---|
| Phone/FAX: E-mail: | 416-864-5197 FAX: 416-864-5584 ngd@smh.ca |
| Research Interests: | My research lab is primarily interested in the area of genetics of lipid disorders and cardio-metabolic disorders with special emphasis on high density lipoprotein (HDL) metabolism. We use transgenic/knock out mice as models and our tools include in vivo experiments, ex vivo and in vitro assays at tissue, cellular, and molecular levels. We are particularly interested in using in vivo mouse models to examine the impact of specific genetic-based dyslipidemic states on atherogenesis, diabetogenesis and more recently, obesity and brown fat development. Detailed analyses of these animal models using cellular, molecular and genetic markers will also be carried out to elucidate the underlying mechanism of such disease processes and their interactions. Such genetic models are also used to study the effects of dietary and drug interventions. |
| Publications: |
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O
Ohashi, Pamela S.,
PhD, FRSC
Professor, Departments of Medical Biophysics and Immunology, University
of Toronto
Director, Immune Therapy Program
Co-Director, Campbell Family Institute for Breast Cancer Research
Senior Scientist, Ontario Cancer Institute/Princess Margaret Hospital,
University Health Network
| Address: | Princess Margaret
Hospital 620 University Avenue, 10th Floor, Room 1030 Toronto, Ontario M5G 2C1 |
|---|---|
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Phone: E-mail: | 416-946-2357 FAX: 416-946-2086 pohashi@uhnresearch.ca |
| Research Interests: | The major focus of my lab is to understand the mechanisms of death and differentiation in immature and mature T cells. In particular, an emphasis is placed on understanding the molecular events that direct T cell fate towards either tolerance or activation. These questions are investigated in the context of understanding autoimmunity (diabetes) and tumor immune surveillance in vivo. |
| Publications: |
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P
Palmert, Mark R.,
MD, PhD
Associate Professor, Department of Pediatrics, University of Toronto
Senior
Associate Scientist, Genetics & Genome Biology Program, Hospital For
Sick Children
| Address: | Division of Endocrinology The Hospital for Sick Children 555 University Avenue Toronto, Ontario M5G 1X8 |
|---|---|
| Phone/FAX: E-mail: | 416-813-6217 FAX: 416-813-6304 mark.palmert@sickkids.ca |
| Research Interests: | I care for children and adolescents with type 1 and type 2 diabetes mellitus. I have also been involved in diabetes related clinical research as a Principal Investigator in the NIH multicentered trial entitled Treatment Options for Type 2 Diabetes in adolescents and Youth (TODAY), which is designed to identify best ways to treat type 2 diabetes in youth. I have also been Principal Investigator the Clinical Coordinating Center for the NIH/NIDDK funded Epidemiology of Diabetes Intervention and Complications (DCCT/EDIC). Currently, my diabetes related research includes membership in the Hvidoere Study Group of Childhood Diabetes and using technology to enhance diabetes self-management. |
| Publications: |
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Parra, Esteban J.,
PhD
Associate Professor, Department of Anthropology, University of Toronto
| Address: | University of Toronto at Mississauga 3359 Mississauga Road North, Room 2002, South Building Mississauga, Ontario L5L 1C6 |
|---|---|
| Phone/FAX: E-mail: Web site: |
905-828-3889 FAX: 905-828-3792 esteban.parra@utoronto.ca |
| Research Interests: | Type 2 diabetes is one of the most serious public health issues in Canada and on a global scale. There are striking differences in prevalence among ethnic groups. The prevalence of type 2 diabetes among Aboriginal people is higher than in the general population, and elevated risk has also been described for other groups, such as Hispanics. One of the major goals of Dr. Parra’s research is to identify type 2 diabetes genetic risk factors in Hispanic populations, using different approaches, such as candidate gene studies, admixture mapping and genome-wide association. |
| Publications: |
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Paterson, Andrew D.
Associate Professor, Dalla Lana School of Public Health, University of
Toronto
Canada Research Chair in Genetics of Complex Disease
Senior
Scientist, Program in Genetics and Genome Biology, Hospital for Sick
Children
| Address: | MaRS/Toronto Medical Discovery
Tower 101 College Street, Room 15-707 Toronto, Ontario M5G 1L7 |
|---|---|
| Phone/FAX: E-mail: Web site: | 416-813-6994 FAX: 416-813-2150 andrew.paterson@utoronto.ca http://www.sickkids.ca/AboutSickKids/Directory/People/P/Andrew-Paterson.html |
| Research Interests: | Long-term complications of diabetes, including eye and kidney disease cluster in families suggesting that genetic factors may be involved. Using DNA from large numbers of people with diabetes who have their complications measured, we are using high throughput methods to measure all of the common genetic variation in the human genome to identify which ones are associated with specific complications. In addition, we are identifying genetic loci that are associated with the major risk factors for diabetes complications – glycemia, blood pressure, body composition and lipids. |
| Publications: |
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Perkins, Bruce, MD
Assistant Professor, Department of Medicine, Division of Endocrinology
and Metabolism, University of Toronto
Staff Physician, University Health Network
| Address: | Toronto General Hospital 200 Elizabeth Street, EN 12-218 Toronto, Ontario M5G 2C4 |
|---|---|
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Phone/FAX: E-mail: | 416-340-4800 Ext. 8019 FAX: 416-340-3236 bruce.perkins@uhn.on.ca |
| Research Interests: |
My research initiatives focus on using epidemiological
techniques to explore the natural history of diabetes
complications and novel strategies for their prevention. My
major clinical research areas include:
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| Publications: |
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Poussier, Philippe,
MD
Associate Professor,
Department of Medicine, Division of Endocrinology and Metabolism, and
Department of Immunology, University of Toronto
| Address: | Sunnybrook Health Science Centre
Research Institute 2075 Bayview Avenue, Room A3.38 Toronto, Ontario M4N 3M5 |
|---|---|
|
Phone/FAX: E-mail: Web site: | 416-480-6136 FAX:
416-480-4375 philippe.poussier@sri.utoronto.ca http://sunnybrook.ca/research/team/member.asp?t=12&m=131&page=172 |
| Research Interests: | The objective of our research program is to identify type 1 diabetes (T1D) susceptibility genes in the spontaneously diabetic BB rat, and to characterize the immune mechanisms underlying allelic variation at these susceptibility loci. In particular, we are focusing on genes that appear to be shared between humans and the BB rat. These genetic studies combine linkage analyses, development and characterization of congenic and mutant lines of animals, transfected cell lines. We are also studying the role of differential colonization of the intestine by commensal bacteria on the development of antipancreatic autoimmunity with the objective to understand how environmental changes can affect the expression of diabetogenic genotypes. Another topic of research using transgenic murine models of type 1 diabetes is the characterization of the molecular mechanisms involved in the homing of diabetogenic T cells to pancreatic islets. |
| Publications: |
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Prud'homme, Gérald J.,
MD, FRCPC
Professor, Department of Laboratory Medicine and Pathobiology,
University of Toronto
Clinician-Scientist, St. Michael's Hospital
| Address: | St. Michael's Hospital Department of Laboratory Medicine 30 Bond St. Toronto, ON M5B1W8 |
|---|---|
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Phone/FAX: E-mail: Web site: | 416-864-6060 Ext. 3147 prudhommeg@smh.ca www.stmichaelshospital.com |
| Research Interests: | Research in my laboratory focuses on the immunology of type 1 diabetes, and the development of new drugs and therapies for diabetes. We are studying some key molecules involved in immunopathological diseases, including transforming growth factor beta, neuropilin and the aryl hydrocarbon receptor. This work requires the application of a wide variety of immunological, molecular biological and biochemical techniques, in relevant disease models. |
| Publications: |
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Q
Quaggin, Susan,
MD, FRCPC
Associate Professor, Department of Medicine, University of Toronto
| Address: | Mount Sinai Hospital, Samuel Lunenfeld
Research Institute 600 University Avenue, Room 855 Toronto, Ontario M5G 1X5 |
|---|---|
| Phone/FAX: E-mail: |
416-586-4800 Ext.2859 FAX:
416-586-8588 quaggin@mshri.on.ca |
| Research Interests: | The Role of VEGF-A in Diabetic Nephropathy. Diabetic nephropathy (DN) is the leading cause of end-stage renal disease in North America and the largest component of total cost of diabetes care. The basic mechanisms and pathogenesis of diabetic nephropathy are not well understood. The role of vascular endothelial growth factor A in the pathogenesis of diabetic complications is suggested by increased expression of this pro-angiogenic factor in retina and glomeruli prior to the onset of major changes. Furthermore, the nephropathy in a diabetic rat model responded to reduction of systemic VEGF levels with a blocking VEGF antibody. In our lab, we have generated a number of molecular tools and mouse models that permit us to manipulate the local production of VEGF-A in the glomeruli of living mice. Through the administration of doxycycline in the drinking water of transgenic mice, we are able to upregulate the production of the major isoform of VEGF-A 5-fold. Following only 4 days of induction, these mice develop progressive albuminuria similar to clinical presentation of patients with new onset type diabetes. Following 2 months of induction, the glomeruli of these mice exhibit features characteristic of diabetic nephropathy including nodular sclerosis, basement mebrane thickening and mesangial expansion. We will now use these murine models to further dissect the role of VEGF-A signaling in diabetic nephropathy in euglycemic and hyperglycemic settings and as a preclinical model to test the potential role of systemic VEGF inhibitors and TGF-beta inhibitors in slowing progression of diabetic changes. |
| Publications: |
R
Remington, Gary
MD, PhD, FRCPC
Professor of Psychiatry, Faculty of Medicine,
Head, Schizophrenia Program;
Deputy Director, Research and Education, Centre for Addiction and Mental Health
| Address: | Centre for Addiction and Mental Health (CAMH) 250 College Street Toronto |
|---|---|
| Phone/FAX: E-mail: | 416-535-8501Ext. 4750
FAX: 416-979-4292 gary_remington@camh.net |
| Research Interests: | The newer antipsychotics, now widely used in the treatment of psychosis and numerous other psychiatric disorders as well, have been linked to a marked liability for weight gain and associated metabolic disturbances. Our work involves both animals and humans in an effort to better understand the underlying pharmacological mechanisms and distinguish weight gain-related changes from effects that may be medication-specific and independent of the weight issue. |
| Publications: |
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Retnakaran, Ravi,
MD, FRCPC
Assistant Professor, Department of Medicine, Division of Endocrinology
and Metabolism, University of Toronto
| Address: | Leadership Sinai Centre for Diabetes Mount Sinai Hospital 60 Murray Street, Suite L5-025, Mailbox 21 Toronto, Ontario M5T 3L9 |
|---|---|
| Phone/FAX: E-mail: | 416-586-4800 ext 3941
FAX: 416-586-8853 rretnakaran@mtsinai.on.ca |
| Research Interests: | My research focuses on the early pathophysiology of type 2 diabetes (T2DM) and cardiovascular disease (CVD). A central component of this program is a large prospective observational cohort study of women recruited in pregnancy and followed longitudinally for several years postpartum. The concept underlying this program is that the gluco-regulatory response to the metabolic challenge posed by pregnancy provides unique physiologic insight into a woman’s future risk of metabolic and vascular disease. Indeed, in a series of papers, we have demonstrated that a woman’s glucose tolerance status in pregnancy provides a window to her future risk of both T2DM and CVD, ranging from high risk (in women with gestational diabetes (GDM)) to intermediate risk (in women with mild abnormalities of glucose tolerance in pregnancy) to low risk (in women that maintain normal antepartum glucose homeostasis). Thus, longitudinal cardio-metabolic characterization of a cohort of women reflecting the full spectrum of glucose tolerance in pregnancy can provide insight into early events in the pathophysiology of T2DM and CVD. Given the central role of beta-cell dysfunction in the pathophysiology of T2DM, another major interest in my research program is the evaluation of beta-cell function on oral glucose tolerance test and meal tolerance test. |
| Publications: |
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Rocheleau, Jonathan V.,
PhD
Assistant Professor, Institute of Biomaterials and Biomedical
Engineering, University of Toronto
Assistant Professor, Departments of Medicine and Physiology, University
of Toronto
Affiliated Scientist, Toronto General Research Institute, University
Health Network
| Address: | MaRS Centre, Toronto Medical Discovery
Tower 101 College Street, 10th Floor, Room 10-707 Toronto , Ontario M5G 1L7 |
|---|---|
| Phone/FAX: E-mail: Web site: |
416-581-7839 FAX: 416-581-7839 Jon.Rocheleau@utoronto.ca http://individual.utoronto.ca/Rocheleau |
| Research Interests: | Interaction between pancreatic islets and vascular endothelial cells is necessary for the maintenance of beta-cell mass and function. Aside from acting as a conduit for molecular oxygen, vascular endothelial cells in vivo secrete the majority of islet extracellular matrix (ECM). This ECM likely provides a permissive signal for beta-cell proliferation, contributing to the coordinated hyperplasia of these tissues during the early stages of Type 2 diabetes. This ECM also provides a reservoir for heparin binding growth factors that further modulate this hyperplasia, including fibroblast growth factor (FGF) and vascular endothelial growth factor-A (VEGF-A). We hypothesize that communication between beta-cells and vascular endothelial cells directs the proliferation and function of both tissues. |
| Publications: |
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Rozakis Adcock, Maria
Associate Professor, Department of Laboratory Medicine & Pathobiology,
University of Toronto
| Address: | University of Toronto, Medical Sciences
Building 1 King's College Circle, Room 6238 Toronto, Ontario M5S 1A8 |
|---|---|
| Phone/FAX: E-mail: | 416-946-0392 FAX: 416-978-5959 maria.rozakis@utoronto.ca |
| Research Interests: | The prevalence of obesity is increasing worldwide, as is the prevalence of obesity-related co-morbidity. Obesity is associated with an increased risk of developing insulin resistance and Type II diabetes (T2D). A universal observation in both humans and rodents is that impaired insulin secretion in is caused by a marked increase in pancreatic β-cell destruction that outweighs the rate of β-cell replication and renewal. Currently, the factors that instigate an increased rate of β-cell death during the pathogenesis of T2D are not fully understood. Research in the Rozakis lab is focused on understanding molecular and cellular processes that contribute to insulin resistance and Type II diabetes. Our lab has identified novel transcriptional networks that serve to regulate pancreatic islet regeneration and glucose homeostasis. We use a combination of biochemical, proteomic approaches and transgenic animal models to understand the molecular circuitry involved in transducing the unique actions of insulin on its target tissues. |
| Publications: |
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S
Scholey, James W.,
MD, FRCPC
Professor, Department of Medicine, University of Toronto
Staff Physician (Nephrology), University Health Network and
| Address: | Toronto General Hospital 200 Elizabeth Street, Room 8N-859 Toronto, Ontario M5G 2C4 |
|---|---|
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Phone/FAX: E-mail: | 416-340-5093 FAX: 416-340-49999 james.scholey@utoronto.ca |
| Research Interests: | Research in my laboratory at the |
| Publications: |
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Sefton, Michael
Professor,
Institute of Biomaterials and Biomedical Engineering, University of
Toronto
| Address: | University of
Toronto, Donnelly Centre for Cellular and Biomolecular Research 160 College St., Room 406 Toronto, Ontario M5S 3E1 |
|---|---|
| Phone/FAX: E-mail: | 416-978-3088 FAX: 416-978-4317 michael.sefton@utoronto.ca http://ibbme.utoronto.ca/faculty/core/sefton.htm |
| Research Interests: | Biomaterials and tissue engineering: microencapsulation of mammalian cells including pancreatic islets; cell transplantation; immune and inflammatory responses to biomaterials; thrombogenicity of biomaterials. |
| Publications: |
Shah, Baiju, MD,
PhD, FRCPC
Assistant Professor, Department of Medicine, University of Toronto
Staff
Endocrinologist, Sunnybrook Health Sciences Centre
Scientist, Institute for Clinical Evaluative Sciences
Scientist,
Sunnybrook Research Institute
| Address: | Institute for Clinical Evaluative
Sciences 2075 Bayview Avenue, Suite G106 Toronto, Ontario M4N 3M5 |
|---|---|
| Phone/FAX: E-mail: | 416-480-4706 FAX: 416-480-6048 baiju.shah@ices.on.ca |
| Research Interests: | My research focus is on the quality of and outcomes of diabetes care. Much of this work is done using linkage of large health care administrative data bases. My three main areas of interest are: a) the influence of different care models on diabetes quality and outcomes, b) gestational diabetes care and outcomes, and c) diabetes in vulnerable populations, including ethnic, immigrant and aboriginal communities. |
| Publications: |
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Steiner, George,
MD, BA, MD, FRCPC, FCAHS
Professor Emeritus, Departments of Medicine and of Physiology,
University of Toronto
| Address: | Toronto General Hospital 200 Elizabeth Street, Room 12EN213 Toronto, Ontario, M5G 2C4 |
|---|---|
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Phone/FAX: E-mail: | 416-340-4133 FAX: 416-340-3314 george.steiner@utoronto.ca |
| Research Interests: | Diabetes, lipoproteins and atherosclerosis. |
| Publications: |
T
U
V
van der Kooy, Derek,
PhD
Professor, Department of Molecular Genetics, University of Toronto
| Address: | Terrence Donnelly
Centre for Cellular and Biomolecular Research University of Toronto 160 College Street, Room 1102 Toronto, Ontario CANADA M5S 3E1 |
|---|---|
|
Phone/FAX: E-mail: Web sites: | 416-978-1960 FAX:
416-978-2666 derek.van.der.kooy@utoronto.ca www.utoronto.ca/nbrg |
| Research Interests: | The search for putative precursor cells within the pancreas has been a focus of
extensive research. Adult mouse Pancreas-derived Multipotent Precursor (PMP)
cells, possessing the intriguing capacity to generate cross-germ layer progeny
in the pancreatic and neural lineages, have been identified. Here, genetic
lineage-labelling was used to exclude the neural crest as the developmental
source of PMPs. Notably, we demonstrate that the PMP cell expresses insulin in
vivo, providing reconciliation with reports that new adult b cells are formed
exclusively by self-replication. Further, PMP cells were shown to exist within
adult human islet tissue, each capable of extensive proliferation, self-renewal,
and generation of multiple differentiated pancreatic and neural cell types.
Finally, the newly generated human b cell progeny were found to display
regulated insulin secretion. These findings demonstrate that the adult mammalian
pancreas contains a population of insulin+ multipotent stem cells, capable of
contributing to the neural and pancreatic lineages. |
| Publications: |
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Volchuk, Allen,
PhD
Assistant Professor, Department of Biochemistry; Department of
Physiology, University of Toronto
Scientist, Division of Cellular & Molecular
Biology, Toronto General Research Institute,
University Health Network
| Address: | MaRSCentre, Toronto Medical Discovery Tower 101 College Street, 10th Floor, Room 706 Toronto, Ontario, M5G 1L7 |
|---|---|
| Phone: E-mail: Web sites: | 416-581-7675 FAX:
416-581-7880 avolchuk@uhnres.utoronto.ca http://biochemistry.utoronto.ca/volchuk/bch.html http://www.physiology.utoronto.ca/res/list/volchuk.htm |
| Research Interests: |
Endoplasmic Reticulum (ER) stress and the Unfolded Protein
Response in Pancreatic beta-cells Pancreatic beta-cell dysfunction in type 2 diabetes involves defective insulin secretion and production and increased beta-cell death. ER stress has emerged as a factor that may contribute to both beta-cell defects. Research in the Volchuk laboratory focuses on the molecular mechanism of the ER stress response in pancreatic beta-cells and the mechanisms that lead to cell death. The lab uses a variety of current biochemical and cell biological techniques for these studies. Current projects include examining the ER stress response in pancreatic beta-cells using cell culture models and isolated islets. The lab also uses animal models of type 2 diabetes and transgenic mouse models to examine the role of ER stress in beta-cell dysfunction. |
| Publications: |
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Vranic, Mladen,
O.C.,
O.Ont, MD, DSc, FRSC,
FRCP(C), FCAHS
Professor Emeritus, Departments of Physiology and Medicine,
University of Toronto
Laureate, Canadian
Medical Hall of Fame
| Address: | University of Toronto, Medical Sciences
Building 1 King's College Circle, Room 3269 Toronto, Ontario M5S 1A8 |
|---|---|
| Phone/FAX: E-mail: | 416-978-4126 FAX: 416-978-4373 mladen.vranic@utoronto.ca |
| Research Interests: | The research in Dr. Vranic’s laboratory centres on the physiological and
molecular mechanisms whereby exercise can prevent diabetes in the ZDF rats.
Initially we have shown that exercise increases expansion of β-cell mass due in
part to hypertrophy and hyperplasia. The area of GLUT-2 and protein-kinase-B is
also elevated formation of ubiquitinated protein aggregates response to cellular
oxidative stress is prevented by exercise. Paradoxically, mild, intermittent
stress has similar effects to exercise. This is in contrast to continuous
stress, which deteriorates diabetes. Finally, volitional exercise decreases
oxidative stress markers and inflammation associated with decreased
hyperglycemia and insulin resistance in the reduced expression of the main
gluconeogenic enzyme PEPCK. In insulin-treated diabetics, hypoglycemia occurs frequently, and presents a major acute complication. This is mainly due to reduced or absent counter-regulatory hormones. We have demonstrated that an antagonist of somatostatin receptor number 2 can dramatically restore glucagon response and also improves the responses of corticosterone and epinephrine. This observation has been patented and offers a new possibility of prevention of hypoglycemia. Relaxation of intensive insulin treatment reduces the risk of hypoglycemia but increases the risk of long-term diabetic complications. |
| Publications: | Vranic, M. Odyssey between Scylla and Charybdis through storms of carbohydrate metabolism and diabetes: a career retrospective. Am J Physiol Endocrinol Metab, 299: E849-E867, 2010. |
W
Wang, Qinghua, MD, PhD
Associate Professor, Departments of Physiology and Medicine, University
of Toronto
| Address: | St. Michael's Hospital Division of Endocrinology & Metabolism 30 Bond St., Room 7005, Queen Wing Toronto, Ontario M5B 1W8 |
|---|---|
| Phone/FAX: E-mail: Web site: |
416-864-6060 Ext.6767 FAX: 416-864-6043 qinghua.wang@utoronto.ca Department of Physiology website profile |
| Research Interests: | Research in the Wang lab is focused on understanding the biology the pancreatic islet, im particular the regulation of islet cell secretion and function. We are also studying the biology of GLP-1, an incretin hormone released from gut cell in response to feeding. Among patients with diabetes, while the production of insulin is insufficient, release of GLP-1 is reduced. However, glucagon and glucose production is too high. While seeking a means to increase pancreatic insulin production, enhance GLP-1 action, we are also studying the signaling and molecular control of islet cell-cell interactions in regulating islet beta-cell function and glucose homeostasis during the development of diabetes. Our research is fundamental and translational, aiming at developing new therapeutic strategies that could enable patients with diabetes to permanently manage the disease and effectively avoid its associated complications. |
| Publications: |
|
Wen, Xiao-Yan, MD, PhD
Assistant Professor, Department of Medicine, University of
Toronto
Scientist, Keenan Research Centre, Li Ka Shing Knowledge Institute, St.
Michael’s Hospital
Director, Zebrafish Centre for Advanced Drug Discovery, St. Michael’s
Hospital
| Address: | St. Michael's Hospital 30 Bond Street Room 8-019, Queen Wing Toronto, Ontario, Canada M5B 1W8 |
|---|---|
|
Phone/FAX: E-mail: Web site: | Phone: 416-864-6060 x3120; FAX:
416-416-864-5476 x.wen@utoronto.ca http://www.stmichaelshospital.com/research/profile.php?id=wen&navId=3.3.0.0.0 |
| Research Interests: | The zebrafish has emerged as an important vertebrate model organism for annotation of gene function, modeling human disease and drug discovery. My lab is developing a few projects to: (1) create fluorescent zebrafish models to genetically label pancreatic beta and alpha cells, and then perform lineage specific cell ablation and study their regeneration and relationship; (2) generate novel zebrafish models for anti-diabetic compound screen. We are currently creating a reporter zebrafish strain for monitoring Phosphoenolpyruvate Carboxykinase (PEPCK) activity, a rate-limiting enzyme in gluconeogenesis. Compounds modulating PEPCK activities in zebrafish and may be developed as novel potent anti-diabetic drugs. |
| Publications: | Wang C, Tao W, Wang Y, Bikow J, Lu B, Keating A, Verma S, Parker TG, Han R, Wen XY. Rosuvastatin, identified from a zebrafish chemical genetic screen for antiangiogenic compounds, suppresses the growth of prostate cancer. Eur Urol. 2010 Sep;58(3):418-26. |
Westall, Carol A.
Professor of Ophthalmology and Vision Sciences, University of Toronto
Director of
Visual Electrophysiology, Ophthalmology
Senior Associate Scientist,
Hospital for Sick Children Research Institute
| Address: | Hospital For Sick Children Department of Ophthalmology & Vision Sciences 555 University Avenue Toronto, Ontario M5G 1X8 |
|---|---|
| Phone/FAX: E-mail: Web site: |
416-813-6516 FAX: 416-813-7661 carol@sickkids.ca Hospital For Sick Children web site profile |
| Research Interests: | One of the changes commonly observed in patients with type I Diabetes, is impaired vision. As Director of a world class pediatric visual Electrophysiology unit I have the tools to describe visual processing using the latest technologies for objective neuro-retinal assessment. We found previously functional defect within the visual pathways as a result of Type 1 Diabetes (IOVS 2005; IOVS 2010). This finding lead to our current study (CIHR funded) aimed at identifying which neuro-retinal markers precede detectable vascular dysfunction in type 1 diabetes and which markers of are predictive of subsequent sight-threatening diabetic retinopathy. We received major funding from the Canadian Foundation for Innovations for the purchase and of Multi-model Adaptive Optics Enhanced Retinal Imaging. Our investigation of cellular and functional changes from individual retinal layers will represent the first structural and functional assessment in this population. Our study was ranked #1 in the CIHR committee; “Both reviewers considered the research proposed to be relevant; diabetic retinopathy is a significant cause of blindness and the research proposed could lead to new treatments for this eye disease” (Scientific Officer, CIHR). These studies are a unique collaboration between SickKids Ophthalmology (Dr. Wai-Ching Lam), University of Waterloo Physics (Dr Melanie Campbell) and SickKids Endocrinology (Dr. Farid Mahmud). |
| Publications: | Lakhani E. Wright T, Abdolell M, Westall C. (2010) Insufficient long-term glycaemia control is associated with multifocal ERG defects in adolescents with type 1 diabetes. Invest Ophthalmol Vis Sci. 2010 Oct;51(10):5297-303. |
Wheeler, Michael B.,
PhD
Professor, Departments of Medicine and Physiology, University of
Toronto
Senior Scientist, Toronto General Hospital Research Institute,
University Heath Network
| Address: | University of Toronto Medical Sciences Building, Room 3352 1 King’s College Circle Toronto, ON M5S 1A8 |
|---|---|
| Phone/FAX: E-mail: | University of Toronto office Phone: 416-978-6737 FAX: 416-978-4940 E-mail: michael.wheeler@utoronto.ca Toronto General Hospital (TMDT) office Phone: 416-581-8462 mwheeler@uhnresearch.ca |
| Research Interests: | Our research is focussed on developing novel strategies to treat Type1 and Type
2 diabetes using multidisciplinary approaches, which combine information gained
from genetic models of diabetes, genomics/proteomics, molecular biology and cell
biology. Defects in pancreatic endocrine function are central factors in the
pathology of diabetes. As such, we are currently investigating several avenues
of research that explore pancreatic islet function in both healthy and diseased
states. These include the role oxidative stress, reactive oxygen species and
uncoupling proteins in the development of diabetes. We also explore the roles of
membrane bound proteins like transporter, ion channels and receptors on
pancreatic islet function. Another major thrust of our research is to work
closely with stem cell biologists in Toronto to produce and characterize stem
cell-derived beta cells for potential use in treating Type 1 diabetes. Members of the Wheeler lab have access to state-of-art facilities at both the University of Toronto and the University Health Network at TMDT and have forged collaborations with world-class research teams working in the diabetes field. The laboratory is affiliated with the Endocrinology and Diabetes Research Group in the Department of Physiology at U of Toronto and the Banting and Best Diabetes Centre at UHN. As such the Wheeler lab is an excellent training environment for undergraduates, M.Sc. and Ph.D. candidate as well as post-doctoral fellows and residents interested in diabetes. |
| Publications: |
|
Wherrett, Diane K.,
MD, FRCPC
Associate Professor, Department of Paediatrics, Division of
Endocrinology, University of Toronto
Program Director, Paediatric Endocrinology Training Program, University of Toronto
| Address: | Hospital for Sick Children, Division of
Endocrinology 555 University Avenue Toronto, Ontario M5G 1X8 |
|---|---|
| Phone/FAX: E-mail: | 416-813-8159 FAX: 416-813-6304 diane.wherrett@sickkids.ca |
| Research Interests: | My research focuses in clinical studies of the pathogenesis of type 1 diabetes and prevention of beta cell loss prior to the development of type 1 diabetes and at onset. I am the principal investigator for the Canadian Clinical Centre of Type 1 Diabetes TrialNet, a NIH sponsored international trial group. Our site is currently involved in multiple TrialNet studies: Natural History Study Of the Development Of Type 1 Diabetes, Effects Of Rituximab On The Progression Of Type 1 Diabetes In New Onset Subjects, Oral Insulin For Prevention Of Diabetes In Relatives At Risk For Type 1 Diabetes Mellitus ,Effects of CTLA-4 Ig (Abatacept) On The Progression of Type 1 Diabetes In New Onset Subjects, Effects of Recombinant Human Glutamic Acid Decarboxylase (rhGAD65) Formulated in Alum (GAD-alum) on the Progression of Type 1 Diabetes in New Onset Subjects Study, Effects of Canakinumab On The Progression of Type 1 Diabetes In New Onset Subjects. TrialNet has 11 clinical centres across Canada. |
| Publications: |
|
Winer, Dan,
MD, FRCPC
Assistant Professor, Department of Laboratory Medicine and Pathobiology
Scientist, Division of Cellular and Molecular
Biology, Toronto General Research Institute
Endocrine Pathologist, Department of Pathology, University Health
Network
| Address: | 200 Elizabeth Street Department of Pathology, 11th floor, 11E-424A Toronto, |
|---|---|
| Phone/FAX: E-mail: | Phone: 416-340-3190
Fax: 416-340-5517 dan.winer@uhn.ca |
| Research Interests: | Our primary research focus is to elucidate immune mediated
pathways governing obesity related insulin resistance. Obesity and its
major complications, including insulin resistance, are a major global cause of
morbidity and mortality, and have reached epidemic proportions. Evidence
is mounting that a significant contributing cause of insulin resistance is
chronic inflammation in visceral adipose tissue (VAT). This inflammation
was initially thought to be driven solely by macrophages of the innate immune
system attracted to dying adipocytes in fat. Recently, in collaboration
with the Hospital for Sick Children, and |
| Publications: |
|
Wojtowicz, J. Martin
Professor, Department of Physiology, University of Toronto
| Address: | University of Toronto,
Department of Physiology 1 Kings College Circle Medical Sciences Building, Room 3214 Toronto, Ontario M5S 1A8 |
|---|---|
| Phone: E-mail: Web site: | 416-978-2899 martin.wojtowicz@utoronto.ca www.newneuron.com |
| Research Interests: | Research involves studies of pathological changes in the brain related to learning and memory. Specifically, diabetes can cause reduction in rate of neurogenesis in adult brain, which in turn, can lead to impaired learning and memory. Specific signals leading to impairment of neurogenesis and ways of preventing or compensating for impaired memory are under investigation. |
| Publications: | S. Becker, G. M. MacQueen, and J. M. Wojtowicz. The computational modeling and empirical studies of hippocampal neurogenesis-dependent memory: effects of interference, stress and depression. Brain Res. 1299:45-54, 2009. |
Wolever, Thomas M. S.
Professor, Department of Nutritional Sciences and Department of
Medicine, University of Toronto
| Address: | Department of Nutritional Sciences 150 College Street, University of Toronto Toronto, Ontario M5S 3E2 |
|---|---|
| Phone/FAX: E-mail: Web sites: | 416-978-5556 FAX:
416-978-5882 thomas.wolever@utoronto.ca http://www.utoronto.ca/nutrisci/faculty/Wolever/ http://www.gilabs.com |
| Research Interests: | Carbohydrates in human nutrition, specifically the effects of glycemic index, sugars, starch, and dietary fiber in relation to diabetes, hyperlipidemia and colonic fermentation |
| Publications: |
|
Woo, Minna, MD,
FRCPC, PhD
Associate Professor, Department of Medicine, Division of
Endocrinology & Metabolism; and Department of Medical Biophysics,
University of Toronto
Scientist, Keenan Research Centre, Li Ka Shing Knowledge Institute, St.
Michael's Hospital
Staff Endocrinologist, St. Michael’s Hospital
| Address: | Ontario Cancer
Institute 610 University Avenue, Suite 8-113 Toronto, Ontario M5G 2N9 |
|---|---|
| Phone/FAX: E-mail: | 416-946-4501 X3971 FAX:
416-946-2086 mwoo@uhnresearch.ca http://medbio.utoronto.ca/faculty/woo.html |
| Research Interests: | The major research focus in the Woo laboratory is to elucidate molecular mechanisms that determine pathogenesis of insulin resistance and type 2 diabetes. Our research interests include elucidating mechanisms of islet apoptosis and survival in physiological and diabetic states. We are interested in many of the fundamental genes involved in cell survival and apoptosis such as caspases, tumour suppressors and oncogenes. Many of these fundamental genes have essential physiological roles in metabolic tissues such as liver, muscle, adipose tissue, and the pancreatic islets. Using genetically engineered mice, we examine the whole body physiology as well as take biological, biochemical and molecular approaches to define physiological roles in specific tissues, in addition to defining its potential pathogenic role in diabetes. These approaches to clarify tissue-specific molecular mechanisms have wide implications for treatment of both type 1 and type 2 diabetes. |
| Publications: |
|
Woodgett, James
Department of Medical Biophysics, University of Toronto
Director, Samuel
Lunenfeld Research Institute, Mount Sinai Hospital
| Address: | Samuel Lunenfeld
Research Institute Mount Sinai Hospital 600 University Avenue, Room 982 Toronto, Ontario M5G 1X5 |
|---|---|
| Phone/FAX: E-mail: Web site: | 416-586-8811 FAX:
416-586-8839 woodgett@lunenfeld.ca http://www.lunenfeld.ca/researchers/woodgett |
| Research Interests: | Our laboratory is primarily interested in the abrogation of signal transduction pathways in human disease, in particular the phosphatidylinositol 3' kinase pathway and the Wnt pathway. Both are implicated in cancer and diabetes. We are studying several protein kinase components of these pathways, such as Protein Kinase B (PKB/Akt), Serum and Glucocorticoid-inducible Kinase 3 (SGK3) and Glycogen Synthase Kinase-3 (GSK-3). GSK-3 is associated with Alzheimer's Disease, bipolar disorder and type II diabetes. There are two mammalian genes for GSK-3, termed alpha and beta and we have generated both conventional and tissue-specific knockout mice strains of each. For example, we have generated mice that specifically lack GSK-3beta in either skeletal muscle and have characterized the insulin and glucose tolerances of these animals. GSK-3 is inhibited by insulin signalling and thus the knockouts are providing insight into the utility of GSK-3 inhibitors as sensitizers for insulin-resistant patients. We are also identifying novel targets for GSK-3 (and other protein kinases) which will help us understand the molecular mechanisms by which GSK-3 influences blood glucose responses. |
| Publications: |
|
Wu, Xiao Yu (Shirley)
Professor, Leslie Dan Faculty of Pharmacy
Advanced Pharmaceutics & Drug Delivery Laboratory
| Address: | University of Toronto Leslie Dan Pharmacy Building, Room 1103 144 College Street Toronto, Ontario M5S 3M2 |
|---|---|
| Phone/FAX: E-mail: Web site: | 416-978-5272 http://pharmacy.utoronto.ca/about/faculty/Shirley_Wu.htm |
| Research Interests: | Advanced pharmaceutics and drug delivery. Our research interests and activities related to diabetes treatment include microencapsulation of enzymes, therapeutic hormones and polypeptides; artificial islet cells; nanomaterials such as bio-inorganic, polymer-metal and polymer-lipid hybrid nanoparticles and nanocomposite membranes; nanoparticulate contrast agents and fluorophores for in vitro/in vivo imaging; ROS-regulating systems; “intelligent” drug delivery systems for self-regulated drug delivery; nanotechnology-enabled glucose-responsive closed-loop insulin delivery implants for diabetic research animals and for clinical treatment. |
| Publications: |
|
X
Y
Yip, Christopher M.,
PhD, PEng, FAAAS
Associate Professor, Department of Chemical Engineering and Applied
Chemistry; Department of Biochemistry; Institute of Biomaterials and
Biomedical Engineering, University of Toronto
| Address: | 404–164 College
Street Toronto, Ontario, M5S3G9 |
|---|---|
| Phone/FAX: E-mail: Web site: | 416-978-7853 FAX:
416-978-4317 christopher.yip@utoronto.ca http://bigten.med.utoronto.ca |
| Research Interests: | Our primary focus is in single molecule biophysics and specifically the interaction between biomolecules, including membrane receptors. Our primary research tools are single molecule microscopies (confocal / TIRF / atomic force) coupled with high-resolution infrared and fluorescence spectroscopies. We are motivated by a keen interest in the functional integration of these techniques to enable single molecule imaging in live cells. Our past efforts have included direct imaging of isolated insulin receptors in model membranes, single molecule force spectroscopy of insulin self-association, and mapping of glucacon fibril formation, and characterization of insulin crystallization by atomic force microscopy. |
| Publications: |
|
Yu, Catherine
Staff, Division of Endocrinology & Metabolism, St. Michael's Hospital
Assistant Professor, Faculty of Medicine and Dalla Lana School of Public
Health, University of Toronto
Adjunct Scientist, Keenan Research Centre in the Li Ka Shing Knowledge
Institute of St. Michael's Hospital
| Address: | 61 Queen Street East Toronto, Ontario M5C 2T2 |
|---|---|
| Phone/FAX: E-mail: Web site: | - |
| Research Interests: | My research interests lie in the role of patient and clinician behaviour change in knowledge translation. I am particularly interested in the development of innovative strategies for continuing professional development and patient education in chronic disease management, specifically diabetes care. |
| Publications: | Yu CH, Batty HP. Targeting educational interventions to clinician's stage of change. Diabetes Res Clin Pract. 2010 Sep;89(3):e43-e45. Epub 2010 Jun 17. |
Z
Zinman, Bernard, MDCM,
FRCPC, FACP
Professor, Department of Medicine, University of Toronto
Director, Leadership Sinai Centre for Diabetes, Mount Sinai Hospital
Sam and Judy Pencer Family Chair in Diabetes
| Address: | Mount Sinai Hospital 60 Murray Street, 5th Floor Room L5-024, Mail Box 17 Toronto, Ontario M5T 3L9 |
|---|---|
| Phone/FAX: E-mail: | 416-586-8747 FAX:
416-586-4740 zinman@lunenfeld.ca |
| Research Interests: |
|
| Publications: |
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